Staff
| Personal Information | ||
| Name | Volkov, Yuri | |
| College Address | Clinical Medicine, Trinity Centre, S J H |
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| Main Department | Clinical Medicine | |
| College Title | Professor of Molecular & Translational M | |
| yvolkov@tcd.ie | ||
| College Tel | +353 1 896 3263 | |
| Web | http://www.medicine.tcd.ie/molecular-medicine/ | |
| Biography | |
| Prof. Yuri Volkov received his MD from the Moscow Medical Academy and subsequently a PhD in biomedical sciences (Institute of Immunology, Moscow). He has been working at the Department of Clinical Medicine, Trinity College Dublin since 1995 and is currently also one of the Principal Investigators at the Institute of Molecular Medicine. His research interests for a number of years have been focused in leukocyte biology, mechanisms of inflammation and cell adhesion receptors functioning in immune defense and disease development. Among the main achievements in this area was the discovery and characterization of the crucial impact of intracellular phosphorylation enzyme of the protein kinase C family – PKC-beta for the process of T cell migration. Recently, the results of the previous fundamental studies enabled the research group to unveil the previously unknown LFA-1 integrin-mediated mechanism of the immune evasion by the hepatitis C virus, which currently represents one of the most worrying causes of long-term morbidity worldwide. Successful advancement of these studies has been made possible through the implementation of the cutting edge High Content Analysis (HCA) molecular imaging technologies. Prof. Volkov’s group has made a key contribution into the establishing of the multi-user HCA facility at the Institute of Molecular Medicine, which represents a state-of-the art setup in the academic institution at the international level. Recently, the research interests of the group have extended into the applications of nanotechnologies for advanced biomedical studies and NanoMedicine as an emerging scientific discipline. Prof. Volkov has developed a large-scale interdisciplinary alliance between the Departments of Clinical Medicine, Physics, and Chemistry at Trinity College, opening the opportunities to develop new nano-scale diagnostic and drug delivery systems based on magneto-optical nanomaterials and fluorescent semiconductor nanoparticles, or quantum dots. Prof. Volkov is currently also a principal investigator in NanoBiology of the Trinity College’s CRANN – Centre for Research on Adaptive Nanostructures and Nanodevices, where his group is developing the applications of nanoparticles and nanowires for ultra-sensitive research and medical diagnostics. Prof. Volkov is the Trinity College’s lead partner of the EU FW-6 Consortium NanoInteract and of the strategic research cluster BioNanoInteract funded by the Science Foundation of Ireland. | |
| Teaching interests and responsibilities | |
| Undergraduate: Molecular Medicine course developer and co-ordinator (2nd year medical students) Postgraduate: MSc in Molecular Medicine (incorporating Nanomedicine and High Content cell Screening and Analysis) - member of the course co-ordinating group | |
| Professional Qualifications | |
| Qualification | Institution | Class of Degree | Title of Dissertation | Date Conferred |
| Ph.D. | Institute of Immunology, Moscow | |||
| M.D. | I.M. Sechenov Moscow Medical Academy |
| Languages |
| Language | Skill Reading | Skill Writing | Skill Speaking |
| English | Fluent | Fluent | Fluent |
| Russian | Fluent | Fluent | Fluent |
| Research Institutes / Centres / Groups | |
| Research Institutes / Centres / Groups | Description of Role | Date From | Date To |
| Centre for Research on Adaptive Nanostructures and Nanodevices (CRANN) | Principal Investigator | ||
| Dublin Molecular Medicine Center | Principal Investigator | ||
| Trinity Biomedical Sciences |
| Description of Research Interests |
| NanoMedicine and Biomedical applications of nanotechnology. Cell adhesion, migration and intracellular signalling. Live cell and molecular imaging and high content screening and analysis. |
| Research Interests | |||
| Bioengineering | Biomedical applications of nanotechnology | Cell migration & imaging | Diagnostic bioimaging |
| Diagnostics | IMAGE ANALYSIS | IMAGING | IMAGING-SYSTEM |
| INTEGRIN | INTEGRINS | Imaging Techniques | Immune System |
| Immune system | Immunotherapies | Inflammation | Live cell imaging & high throughput (content) screening |
| Medical Devices | Nano Biotechnology | NanoMedicine | Nanomedicine |
| Nanotechnology |
| Publications |
| Peer Reviewed |
| Toetsch S., Olwell P., Prina-Mello A., Volkov Y., The evolution of chemotaxis assays from static models to physiologically relevant platforms, Integrative Biology, 1, (2), 2009, p170 - 181 DOI |
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| Long A., Volkov Y., High Content Analysis approach for targeted gene silencing and probing nanoscale cell responses., European Pharmaceutical Reviews, 1, 2009, p22 - 30 Url |
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| Nabiev I., Mitchell S., Davies A., Williams Y., Kelleher D., Moore R., Gun'ko Y.K., Byrne S., Rakovich Y.P., Donegan J.F., Conroy J., Sukhanova A., Cottel D., Gaponik N., Rogach A., Volkov Y., Nonfunctionalized nanocrystals can exploit a cell's active transport machinery delivering them to specific nuclear and cytoplasmic compartments, Nano Letters, 7, (11), 2007, p3452 - 3461 DOI |
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| Long A., Mitchell S., Kashanin D., Williams V., Prina Mello A., Shvets I., Kelleher D., Volkov Y., A multidisciplinary approach to the study of T cell migration, Annals of the New York Academy of Sciences, 1028, 2004, p313-9 Url |
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| Long A., Kelleher D., Lynch S., Volkov Y., Cutting edge: protein kinase C beta expression is critical for export of Il-2 from T cells, Journal of immunology (Baltimore, Md, 167, (2), 2001, p636-40 Url |
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| More Publications>>> | |
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Last updated 6 May 2009 by .