Staff
| Personal Information | ||
| Name | Lynch, Aileen Maria | |
| College Address | Nursing and Midwifery, D'Olier Street - School Of Nursing |
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| Main Department | School of Nursing & Midwifery | |
| College Title | Assistant Professor | |
| amlynch@tcd.ie | ||
| College Tel | +353 1 896 8571 | |
| Biography | |
| Dr. Aileen Lynch graduated with a BSc in Biochemistry (1995) from NUI, Cork. She then pursued a postgraduate degree in Neuroscience and graduated with an MSc in Neuroscience (1996) from King’s College, London. She carried out a project which investigated the effect of excitatory amino acids on the phosphorylation state of the microtubule-associated protein tau as part of the MSc course. In 2000, Dr. Lynch graduated with a PhD in Neuroanatomy from Imperial College, London. Her PhD involved the study of dendritic spines and glutamatergic cells in schizophrenic post-mortem tissue. Dr. Lynch began her postdoctoral research in the Department of Physiology and the Institute of Neuroscience, Trinity College in 2000 where she investigated the signalling mechanisms which induce cellular damage in the aged brain. In 2002 she was awarded a HRB Postdoctoral Research Fellowship which investigated the age-related deterioration in synaptic function in rat hippocampus. Continuing with the theme of neuroinflammation, in 2005 Dr. Lynch began a SFI Postdoctoral Research Fellowship which investigated if the aged brain is more vulnerable to additional inflammatory insult. In 2007, Dr. Lynch was appointed a lectureship in the School of Nursing and Midwifery and is continuing to research strategies that modulate the inflammatory processes that occur during the ageing process. | |
| Professional Qualifications | |
| Qualification | Institution | Class of Degree | Title of Dissertation | Date Conferred |
| PhD in Neuroanatomy | Imperial College, London | 2000 | ||
| MSc in Neuroscience | King’s College, London | Distinction | 1996 | |
| BSc Biochemistry (Hons) | NUI, Cork | 2.1 | 1995 |
| Membership of Professional Institutions, Associations, Societies |
| Details | Date From | Date To |
| Physiological Society (Affiliate Member) | ||
| American Society for Neuroscience | ||
| British Neuroscience Association | ||
| Neuroscience Ireland |
| Employment Details | |
| Position Held | Job Description | Where | Date From | Date To |
| Lecturer | School of Nursing and Midwifery | 2007 | present | |
| SFI Postdoctoral Research Fellow | Institute of Neuroscience, Physiology Department, Trinity College, Dublin. | 2005 | 2007 | |
| HRB Postdoctoral Research Fellow | Institute of Neuroscience, Physiology Department, Trinity College, Dublin. | 2002 | 2005 | |
| Postdoctoral Researcher | Institute of Neuroscience, Physiology Department, Trinity College, Dublin. | 2000 | 2002 | |
| PhD Researcher | Neurodegenerative Disorders, Imperial College School of Medicine, London. | 1996 | 2000 | |
| More Employment Details>>> | ||||
| Research Interests | |||
| Ageing, memory and other cognitive processes | Alzheimer's disease | Apoptosis | Astrocyte |
| Autoimmunity | BLOOD-BRAIN BARRIER | Cell and tissue maintenance, repair and ageing | Chronic inflamation |
| Consequences of ischemia or hypoxia, convulsive disorders | Cytokine | ENDOTHELIAL CELLS | Immune system |
| Microglia | Multiple Sclerosis | Nervous system, development, plasticiy and ageing | Neurochemistry and neuropharmacology |
| Neurodegeneration | Neuroendocrine Immunology | Neuropharmacology | Neurophysiology |
| Schizophrenia | Stress | TIGHT JUNCTION PERMEABILITY | Tight junction proteins |
| Research Projects | |
| Project title | The impact of age and neuroinflammation on the blood-brain barrier and neurovascular unit |
| Summary | Our findings provide evidence of a structurally and functionally disrupted blood-brain barrier (BBB) with age. IL-1beta signalling mediates the tight junction protein disruption, as evidenced by the increased tight junction expression in aged IL-1R1-/- mice. This may be partially facilitated by its action on matrix metalloproteinases and via signalling through the ERK-MAPK pathway. Such age-related BBB disruption may facilitate the entry of potential neurotoxins into the brain, probably exacerbating neuronal damage with increasing age. |
| Funding Agency | |
| Programme | |
| Type of Project | PhD |
| Date from | October 2009 |
| Date to | September 2012 |
| Person Months | 36 |
| Publications and Other Research Outputs |
| Peer Reviewed |
| Barry CE, Nolan Y, Clarke RM, Lynch A, Lynch MA, Activation of c-Jun-N-terminal kinase is critical in mediating lipopolysaccharide-induced changes in the rat hippocampus , Journal of Neurochemistry, 93, (1), 2005, p221 - 231 Notes: [PMID: 15773921 ] Url DOI |
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| Lynch AM, Moore M, Craig S, Lonergan PE, Martin DS, Lynch MA, Analysis of interleukin-1 beta-induced cell signaling activation in rat, Journal of Biological Chemistry, 278, (51), 2003, p51075 - 51084 | |
| Lynch AM, Lynch MA, The age-related increase in IL-1 type I receptor in rat hippocampus is coupled with an increase in caspase-3 activation., European Journal of Neuroscience, 15, (11), 2002, p1779 - 1788 Notes: [PMID: 12081657] Url DOI |
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| Áine Kelly, Aileen Lynch, Emily Vereker, Yvonne Nolan, Patrice Queenan, Elizabeth Whittaker, Luke A. J. O' Neill, and Marina A. Lynch , The anti-inflammatory cytokine, interleukin (IL)-10, blocks the inhibatory effect of IL-1 beta on long term potentiation - a role for JNK, Journal of Biological Chemistry, 276, (49), 2001, p45564 - 45572 Notes: [PMID: 11581275] TARA - Full Text DOI |
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| More Publications and Other Research Outputs >>> | |